What the FDA labels say about taking them together
Cefdinir and probenecid
Cefdinir's FDA label of October 14, 2025 names probenecid in its drug interactions section; the probenecid label PlainMeds reads does not name cefdinir. The cefdinir label: “As with other β-lactam antibiotics, probenecid inhibits the renal excretion of cefdinir, resulting in an approximate doubling in AUC, a 54% increase in peak cefdinir plasma levels, and a 50% prolongation in the apparent …”
Check it at the source: the cefdinir FDA label on DailyMed (effective October 14, 2025, Lupin Pharmaceuticals, Inc.); the probenecid FDA label on DailyMed (effective January 5, 2021, Lannett Company, Inc.).
What does the cefdinir label say about probenecid?
Cefdinir label, drug interactionsAs with other β-lactam antibiotics, probenecid inhibits the renal excretion of cefdinir, resulting in an approximate doubling in AUC, a 54% increase in peak cefdinir plasma levels, and a 50% prolongation in the apparent elimination t 1/2 .
Source: FDA drug label (Cefdinir), Lupin Pharmaceuticals, Inc., effective October 14, 2025 (SPL set cb7366ce-1778-451f-aba5-65cf73c9b87a), via openFDA; the full label on DailyMed
What does the probenecid label say about cefdinir?
Probenecid's label (effective January 5, 2021) does not name cefdinir in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Probenecid), Lannett Company, Inc., effective January 5, 2021 (SPL set ab497fd8-00c3-4364-b003-b39d21fbdf38), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Cefdinir | Probenecid | |
|---|---|---|
| Labeled for | Bacterial infections | Gout |
| Boxed warning | No | No |
| Pharmacy cost (NADAC) | $0.458 per capsule 300 mg capsule | $0.636 per tablet 500 mg tablet |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once