What the FDA labels say about taking them together
Cefazolin and probenecid
Cefazolin's FDA label of May 14, 2026 names probenecid in its drug interactions section; the probenecid label PlainMeds reads does not name cefazolin. The cefazolin label: “Drug Interactions Probenecid may decrease renal tubular secretion of cephalosporins when used concurrently, resulting in increased and more prolonged cephalosporin blood levels.”
Check it at the source: the cefazolin FDA label on DailyMed (effective May 14, 2026, Hikma Pharmaceuticals USA Inc.); the probenecid FDA label on DailyMed (effective January 5, 2021, Lannett Company, Inc.).
What does the cefazolin label say about probenecid?
Cefazolin label, drug interactionsDrug Interactions Probenecid may decrease renal tubular secretion of cephalosporins when used concurrently, resulting in increased and more prolonged cephalosporin blood levels.
Cefazolin label (Hikma Pharmaceuticals USA Inc., December 31, 2024), drug interactionsDRUG INTERACTIONS The renal excretion of cefazolin is inhibited by probenecid.
Source: FDA drug label (Cefazolin, NDA216109), Hikma Pharmaceuticals USA Inc., effective December 31, 2024 (SPL set 6c7761d3-c154-4802-9876-627cd42913f0), via openFDA
Source: FDA drug label (Cefazolin), Hikma Pharmaceuticals USA Inc., effective May 14, 2026 (SPL set 1dc9de56-e259-4546-a1db-23119a8a088e), via openFDA; the full label on DailyMed
What does the probenecid label say about cefazolin?
Probenecid's label (effective January 5, 2021) does not name cefazolin in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Probenecid), Lannett Company, Inc., effective January 5, 2021 (SPL set ab497fd8-00c3-4364-b003-b39d21fbdf38), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Cefazolin | Probenecid | |
|---|---|---|
| Labeled for | Urinary tract infections | Gout |
| Boxed warning | No | No |
| Pharmacy cost (NADAC) | $1.07 per vial 1 g vial | $0.636 per tablet 500 mg tablet |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once