What the FDA labels say about taking them together
Carvedilol and cobicistat
Cobicistat's FDA label of February 10, 2026 names carvedilol in its drug interactions section; the carvedilol labels PlainMeds reads (2) do not name cobicistat. The cobicistat label: “Clinical monitoring is recommended for coadministration with beta-blockers that are metabolized by CYP2D6.”
Check it at the source: the carvedilol FDA label on DailyMed (effective July 31, 2026, Waylis Therapeutics LLC); the cobicistat FDA label on DailyMed (effective February 10, 2026, Gilead Sciences, Inc.).
What does the carvedilol label say about cobicistat?
Carvedilol's label (effective July 31, 2026) and its 1 other brand-application label do not name cobicistat in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Coreg), Waylis Therapeutics LLC, effective July 31, 2026 (SPL set 07c619c6-4a0c-445e-94fa-664a54f68a39), via openFDA; the full label on DailyMed
What does the cobicistat label say about carvedilol?
Cobicistat label, drug interactionsConcomitant Drug Class/Drug Name: Beta-Blockers: e.g., metoprolol carvedilol timolol; Potential Effect ↑ = Increase, ↓ = Decrease, ↔ = No change: ↑ beta-blockers; Clinical Comment: Clinical monitoring is recommended for coadministration with beta-blockers that are metabolized by CYP2D6.
Source: FDA drug label (Tybost), Gilead Sciences, Inc., effective February 10, 2026 (SPL set 3784c35c-e87f-410c-900b-8fd6313c6010), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Carvedilol | Cobicistat | |
|---|---|---|
| Labeled for | Heart failure, High blood pressure | HIV |
| Boxed warning | No | No |
| Pharmacy cost (NADAC) | $0.0179 per tablet 6.25 mg tablet | n/a |
| Shortage now | No current entry | A presentation being discontinued |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once