What the FDA labels say about taking them together
Carbidopa/entacapone/levodopa and warfarin
Carbidopa/entacapone/levodopa's FDA label of March 19, 2026 names warfarin in its drug interactions section; the warfarin label PlainMeds reads does not name carbidopa/entacapone/levodopa. The carbidopa/entacapone/levodopa label: “Cases of increased INR in patients concomitantly using warfarin have been reported during the post-approval use of entacapone.”
Check it at the source: the carbidopa/entacapone/levodopa FDA label on DailyMed (effective March 19, 2026, Sandoz Inc); the warfarin FDA label on DailyMed (effective May 29, 2026, Amneal Pharmaceuticals LLC).
What does the carbidopa/entacapone/levodopa label say about warfarin?
Carbidopa/entacapone/levodopa label, drug interactionsCases of increased INR in patients concomitantly using warfarin have been reported during the post-approval use of entacapone.
Source: FDA drug label (Carbidopa, Levodopa, and Entacapone), NDA021485 (Orion Pharma), as published by Sandoz Inc, effective March 19, 2026 (SPL set 9c16c0e0-3b97-486b-b7d5-579f5853e2c5), via openFDA; the full label on DailyMed
What does the warfarin label say about carbidopa/entacapone/levodopa?
Warfarin's label (effective May 29, 2026) does not name carbidopa/entacapone/levodopa in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Warfarin Sodium), Amneal Pharmaceuticals LLC, effective May 29, 2026 (SPL set 558b7a0d-5490-4c1b-802e-3ab3f1efe760), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Carbidopa/entacapone/levodopa | Warfarin | |
|---|---|---|
| Labeled for | Parkinson's disease | Blood clots (DVT and PE), Atrial fibrillation |
| Boxed warning | No | Yes |
| Pharmacy cost (NADAC) | $0.695 per tablet 25-100-200 mg tablet | $0.093 per tablet 2 mg tablet |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once