What the FDA labels say about taking them together
Captopril/hydrochlorothiazide and probenecid
Captopril/hydrochlorothiazide's FDA label of February 21, 2023 names probenecid in its drug interactions section; the probenecid label PlainMeds reads does not name captopril/hydrochlorothiazide. The captopril/hydrochlorothiazide label: “Probenecid or Sulfinpyrazone: increased dosage of these agents may be necessary since hydrochlorothiazide may have hyperuricemic effects.”
Check it at the source: the captopril/hydrochlorothiazide FDA label on DailyMed (effective February 21, 2023, Rising Pharma Holdings, Inc.); the probenecid FDA label on DailyMed (effective January 5, 2021, Lannett Company, Inc.).
What does the captopril/hydrochlorothiazide label say about probenecid?
Captopril/hydrochlorothiazide label, drug interactionsProbenecid or Sulfinpyrazone: increased dosage of these agents may be necessary since hydrochlorothiazide may have hyperuricemic effects.
Source: FDA drug label (CAPTOPRIL AND HYDROCHLOROTHIAZIDE), Rising Pharma Holdings, Inc., effective February 21, 2023 (SPL set 0ea90fd4-0da6-4ad2-ab83-6cfbe0ae515e), via openFDA; the full label on DailyMed
What does the probenecid label say about captopril/hydrochlorothiazide?
Probenecid's label (effective January 5, 2021) does not name captopril/hydrochlorothiazide in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Probenecid), Lannett Company, Inc., effective January 5, 2021 (SPL set ab497fd8-00c3-4364-b003-b39d21fbdf38), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Captopril/hydrochlorothiazide | Probenecid | |
|---|---|---|
| Labeled for | High blood pressure | Gout |
| Boxed warning | Yes | No |
| Pharmacy cost (NADAC) | n/a | $0.636 per tablet 500 mg tablet |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once