What the FDA labels say about taking them together
Captopril and furosemide
Captopril's FDA label of February 6, 2026 names furosemide in its drug interactions section; furosemide's label does not name captopril itself but warns about its class (ACE inhibitors).
Check it at the source: the captopril FDA label on DailyMed (effective February 6, 2026, AiPing Pharmaceutical, Inc.); the furosemide FDA label on DailyMed (effective September 30, 2025, Validus Pharmaceuticals LLC).
What does the captopril label say about furosemide?
Captopril label, drug interactionsLoop Diuretics: Furosemide administered concurrently with captopril does not alter the pharmacokinetics of captopril in renally impaired hypertensive patients.
Source: FDA drug label (Captopril), AiPing Pharmaceutical, Inc., effective February 6, 2026 (SPL set 3b789f16-b291-4012-be39-af3beec3ff9a), via openFDA; the full label on DailyMed
What does the furosemide label say about captopril?
Furosemide's label does not name captopril itself; it warns about its class (ACE inhibitors):
Furosemide label, drug interactionsLASIX combined with angiotensin-converting enzyme inhibitors or angiotensin II receptor blockers may lead to severe hypotension and deterioration in renal function, including renal failure.
Furosemide label, drug interactionsAn interruption or reduction in the dosage of LASIX, angiotensin-converting enzyme inhibitors, or angiotensin receptor blockers may be necessary.
Source: FDA drug label (Lasix), Validus Pharmaceuticals LLC, effective September 30, 2025 (SPL set 2c9b4d8f-0770-482d-a9e6-9c616a440b1a), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Captopril | Furosemide | |
|---|---|---|
| Labeled for | High blood pressure, Heart failure, Chronic kidney disease | Heart failure, High blood pressure, Edema (fluid retention) |
| Boxed warning | Yes | No |
| Pharmacy cost (NADAC) | $0.228 per tablet 12.5 mg tablet | $0.490 per mL 20 mg/2 mL vial |
| Shortage now | No current entry | In shortage |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once