What the FDA labels say about taking them together
Candesartan/hydrochlorothiazide and digoxin
Candesartan/hydrochlorothiazide's FDA label of December 22, 2025 names digoxin in its drug interactions section; the digoxin labels PlainMeds reads (3) do not name candesartan/hydrochlorothiazide. The candesartan/hydrochlorothiazide label: “Digitalis − Thiazide-induced hypokalemia or hypomagnesemia may predispose to digoxin toxicity.”
Check it at the source: the candesartan/hydrochlorothiazide FDA label on DailyMed (effective December 22, 2025, ANI Pharmaceuticals, Inc.); the digoxin FDA label on DailyMed (effective December 5, 2024, Advanz Pharma (US) Corp.).
What does the candesartan/hydrochlorothiazide label say about digoxin?
Candesartan/hydrochlorothiazide label, drug interactionsDigitalis − Thiazide-induced hypokalemia or hypomagnesemia may predispose to digoxin toxicity.
Source: FDA drug label (Candesartan Cilexetil and Hydrochlorothiazide), NDA021093 (Ani Pharms), as published by ANI Pharmaceuticals, Inc., effective December 22, 2025 (SPL set bd8d318d-167a-4b26-935d-265dde3193de), via openFDA; the full label on DailyMed
What does the digoxin label say about candesartan/hydrochlorothiazide?
Digoxin's label (effective December 5, 2024) and its 2 other brand-application labels do not name candesartan/hydrochlorothiazide in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (LANOXIN), Advanz Pharma (US) Corp., effective December 5, 2024 (SPL set d91e3646-4c63-4512-ab22-db39c085c4dc), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Candesartan/hydrochlorothiazide | Digoxin | |
|---|---|---|
| Labeled for | High blood pressure | Heart failure, Atrial fibrillation |
| Boxed warning | Yes | No |
| Pharmacy cost (NADAC) | $0.954 per tablet 16-12.5 mg tablet | $0.133 per tablet 125 mcg tablet |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once