What the FDA labels say about taking them together
Calcium gluconate and digoxin
Calcium gluconate's FDA label of May 6, 2024 names digoxin in its drug interactions section; the digoxin labels PlainMeds reads (3) do not name calcium gluconate. The calcium gluconate label: “Hypercalcemia increases the risk of digoxin toxicity.”
Check it at the source: the calcium gluconate FDA label on DailyMed (effective May 6, 2024, Fresenius Kabi USA, LLC); the digoxin FDA label on DailyMed (effective December 5, 2024, Advanz Pharma (US) Corp.).
What does the calcium gluconate label say about digoxin?
Calcium gluconate label, drug interactionsHypercalcemia increases the risk of digoxin toxicity, while digoxin may be therapeutically ineffective in the presence of hypocalcemia.
Calcium gluconate label, warnings and precautionsHypercalcemia increases the risk of digoxin toxicity.
Source: FDA drug label (Calcium Gluconate), Fresenius Kabi USA, LLC, effective May 6, 2024 (SPL set 7f5101e0-abf9-4fcf-8986-c799e3333434), via openFDA; the full label on DailyMed
What does the digoxin label say about calcium gluconate?
Digoxin's label (effective December 5, 2024) and its 2 other brand-application labels do not name calcium gluconate in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (LANOXIN), Advanz Pharma (US) Corp., effective December 5, 2024 (SPL set d91e3646-4c63-4512-ab22-db39c085c4dc), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Calcium gluconate | Digoxin | |
|---|---|---|
| Labeled for | n/a | Heart failure, Atrial fibrillation |
| Boxed warning | No | No |
| Pharmacy cost (NADAC) | n/a | $0.133 per tablet 125 mcg tablet |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once