What the FDA labels say about taking them together
Caffeine and ketoprofen
Caffeine's FDA label of July 29, 2026 names ketoprofen in its drug interactions section; the ketoprofen label PlainMeds reads does not name caffeine. The caffeine label: “Caffeine administered concurrently with ketoprofen reduced the urine volume in 4 four healthy volunteers.”
Check it at the source: the caffeine FDA label on DailyMed (effective July 29, 2026, Sagent Pharmaceuticals); the ketoprofen FDA label on DailyMed (effective February 15, 2026, Misemer Pharmaceuticals, Inc.).
What does the caffeine label say about ketoprofen?
Caffeine label, drug interactionsCaffeine administered concurrently with ketoprofen reduced the urine volume in 4 four healthy volunteers.
Source: FDA drug label (caffeine citrate), Sagent Pharmaceuticals, effective July 29, 2026 (SPL set 5f38c395-0093-4afd-89ec-f96e5dc0934a), via openFDA; the full label on DailyMed
What does the ketoprofen label say about caffeine?
Ketoprofen's label (effective February 15, 2026) does not name caffeine in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Ketoprofen), Misemer Pharmaceuticals, Inc., effective February 15, 2026 (SPL set d0f47ab6-29ff-df07-e053-2a95a90a2b51), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Caffeine | Ketoprofen | |
|---|---|---|
| Labeled for | n/a | Osteoarthritis, Rheumatoid arthritis, Pain |
| Boxed warning | No | Yes |
| Pharmacy cost (NADAC) | $0.083 per tablet 200 mg tablet | $6.46 per capsule 200 mg capsule |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once