What the FDA labels say about taking them together
Cabozantinib and probenecid
Cabozantinib's FDA label (Cometriq) of October 18, 2025 names probenecid in its drug interactions section; the probenecid label PlainMeds reads does not name cabozantinib. The cabozantinib label: “Monitor patients for increased toxicity when MRP2 inhibitors are co-administered with COMETRIQ.”
Check it at the source: the cabozantinib FDA label on DailyMed (effective October 19, 2025, Exelixis, Inc.); the probenecid FDA label on DailyMed (effective January 5, 2021, Lannett Company, Inc.).
What does the cabozantinib label say about probenecid?
Cometriq label (Exelixis, Inc., October 18, 2025), drug interactionsMonitor patients for increased toxicity when MRP2 inhibitors (e.g., abacavir, adefovir, cidofovir, furosemide, lamivudine, nevirapine, ritonavir, probenecid, saquinavir, and tenofovir) are co-administered with COMETRIQ [see Clinical Pharmacology ( 12.3 )].
Source: FDA drug label (Cometriq, NDA203756), Exelixis, Inc., effective October 18, 2025 (SPL set 1a0c3bea-c87b-4d25-bb44-5f0174da6b34), via openFDA
Source: FDA drug label (CABOMETYX), Exelixis, Inc., effective October 19, 2025 (SPL set 3850cce2-6137-42e5-a792-d318c4a4b3b5), via openFDA; the full label on DailyMed
What does the probenecid label say about cabozantinib?
Probenecid's label (effective January 5, 2021) does not name cabozantinib in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Probenecid), Lannett Company, Inc., effective January 5, 2021 (SPL set ab497fd8-00c3-4364-b003-b39d21fbdf38), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Cabozantinib | Probenecid | |
|---|---|---|
| Labeled for | n/a | Gout |
| Boxed warning | No | No |
| Pharmacy cost (NADAC) | n/a | $0.636 per tablet 500 mg tablet |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once