What the FDA labels say about taking them together
Bupropion and telotristat
Telotristat's FDA label of August 6, 2026 names bupropion in its drug interactions section; the bupropion labels PlainMeds reads (4) do not name telotristat. The telotristat label: “Concomitant use of Xermelo may decrease the efficacy of drugs that are CYP2B6 substrates by decreasing their systemic exposure.”
Check it at the source: the bupropion FDA label on DailyMed (effective June 21, 2024); the telotristat FDA label on DailyMed (effective August 6, 2026).
What does the bupropion label say about telotristat?
Bupropion's label (effective June 21, 2024) and its 3 other brand-application labels do not name telotristat in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (BUPROPION HYDROCHLORIDE), Epic Pharma LLC, effective June 21, 2024 (SPL set 9fb44e96-6160-4a4a-90cb-91764c0dcd89), via openFDA; the full label on DailyMed
What does the telotristat label say about bupropion?
Telotristat label, drug interactionsConcomitant use of Xermelo may decrease the efficacy of drugs that are CYP2B6 substrates (e.g., bupropion, efavirenz) by decreasing their systemic exposure.
Source: FDA drug label (Xermelo), TerSera Therapeutics LLC, effective August 6, 2026 (SPL set a4ac9d62-887c-4c8f-b04d-a5f31cec7c86), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Bupropion | Telotristat | |
|---|---|---|
| Labeled for | Depression, Quitting smoking | Diarrhea |
| Boxed warning | Yes | No |
| Pharmacy cost (NADAC) | $0.0785 per tablet 150 mg tablet | n/a |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once