What the FDA labels say about taking them together
Bupropion and metoclopramide
Metoclopramide's FDA label of May 18, 2026 names bupropion in its drug interactions section; the bupropion labels PlainMeds reads (4) do not name metoclopramide. The metoclopramide label: “Strong CYP2D6 inhibitors: See Full Prescribing Information for recommended dosage reductions.”
Check it at the source: the bupropion FDA label on DailyMed (effective June 21, 2024); the metoclopramide FDA label on DailyMed (effective May 18, 2026, ANI Pharmaceuticals, Inc.).
What does the bupropion label say about metoclopramide?
Bupropion's label (effective June 21, 2024) and its 3 other brand-application labels do not name metoclopramide in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (BUPROPION HYDROCHLORIDE), Epic Pharma LLC, effective June 21, 2024 (SPL set 9fb44e96-6160-4a4a-90cb-91764c0dcd89), via openFDA; the full label on DailyMed
What does the metoclopramide label say about bupropion?
Metoclopramide label, drug interactionsStrong CYP2D6 inhibitors (e.g., quinidine, bupropion, fluoxetine, and paroxetine): See Full Prescribing Information for recommended dosage reductions.
Gimoti label (Evoke Pharma, Inc., February 20, 2026), drug interactionsExamples; quinidine, bupropion, fluoxetine, and paroxetine
Source: FDA drug label (Gimoti, NDA209388), Evoke Pharma, Inc., effective February 20, 2026 (SPL set 95269b1f-779c-4ca0-9f86-e74e677f9900), via openFDA
Source: FDA drug label (Metoclopramide), NDA017854 (Ani Pharms), as published by ANI Pharmaceuticals, Inc., effective May 18, 2026 (SPL set 797aad80-0597-42f8-99d5-39de180c3b5a), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Bupropion | Metoclopramide | |
|---|---|---|
| Labeled for | Depression, Quitting smoking | Acid reflux and ulcers, Nausea and vomiting |
| Boxed warning | Yes | Yes |
| Pharmacy cost (NADAC) | $0.0785 per tablet 150 mg tablet | $0.0439 per tablet 10 mg tablet |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once