What the FDA labels say about taking them together
Bupropion and levodopa
Bupropion's FDA label of June 21, 2024 names levodopa in its drug interactions section; the levodopa label PlainMeds reads does not name bupropion. The bupropion label: “Dopaminergic Drugs (levodopa and amantadine): CNS toxicity can occur when used concomitantly with APLENZIN.”
Check it at the source: the bupropion FDA label on DailyMed (effective June 21, 2024); the levodopa FDA label on DailyMed (effective July 20, 2026, Merz Pharmaceuticals, LLC).
What does the bupropion label say about levodopa?
Bupropion label, drug interactionsDopaminergic drugs (levodopa and amantadine): CNS toxicity can occur when used concomitantly with bupropion hydrochloride extended-release tablets (SR).
Source: FDA drug label (Aplenzin, NDA022108), Bausch Health US, LLC, effective March 4, 2026 (SPL set 6494d2d9-0ce4-4126-b1c7-49684395942b), via openFDA
Source: FDA drug label (Wellbutrin Xl, NDA021515), Bausch Health US LLC, effective February 10, 2026 (SPL set a435da9d-f6e8-4ddc-897d-8cd2bf777b21), via openFDA
Source: FDA drug label (Bupropion Hcl Er (Xl), NDA022497), Lifestar Pharma LLC, effective February 4, 2026 (SPL set df959e1b-3f6d-42cf-8521-fe03b5a4ceb8), via openFDA
Source: FDA drug label (BUPROPION HYDROCHLORIDE), Epic Pharma LLC, effective June 21, 2024 (SPL set 9fb44e96-6160-4a4a-90cb-91764c0dcd89), via openFDA; the full label on DailyMed
What does the levodopa label say about bupropion?
Levodopa's label (effective July 20, 2026) does not name bupropion in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Inbrija), Merz Pharmaceuticals, LLC, effective July 20, 2026 (SPL set 077c0f39-a3a2-4b2b-a184-09131889dcfb), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Bupropion | Levodopa | |
|---|---|---|
| Labeled for | Depression, Quitting smoking | Parkinson's disease |
| Boxed warning | Yes | No |
| Pharmacy cost (NADAC) | $0.0785 per tablet 150 mg tablet | n/a |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once