What the FDA labels say about taking them together
Bupropion and haloperidol
Bupropion's FDA label of June 21, 2024 names haloperidol in its drug interactions section; the haloperidol labels PlainMeds reads (2) do not name bupropion. The bupropion label: “Drugs metabolized by CYP2D6: Bupropion inhibits CYP2D6 and can increase concentrations of: antidepressants, antipsychotics, beta-blockers (e.g., metoprolol), and Type 1C antiarrhythmics.”
Check it at the source: the bupropion FDA label on DailyMed (effective June 21, 2024); the haloperidol FDA label on DailyMed (effective April 23, 2026, PD-Rx Pharmaceuticals, Inc.).
What does the bupropion label say about haloperidol?
Bupropion label, drug interactionsDrugs metabolized by CYP2D6: Bupropion inhibits CYP2D6 and can increase concentrations of: antidepressants (e.g., venlafaxine, nortriptyline, imipramine, desipramine, paroxetine, fluoxetine, sertraline), antipsychotics (e.g., haloperidol, risperidone, thioridazine), beta-blockers (e.g., metoprolol), and Type 1C antiarrhythmics (e.g., propafenone, flecainide).
Source: FDA drug label (BUPROPION HYDROCHLORIDE), Epic Pharma LLC, effective June 21, 2024 (SPL set 9fb44e96-6160-4a4a-90cb-91764c0dcd89), via openFDA; the full label on DailyMed
What does the haloperidol label say about bupropion?
Haloperidol's label (effective April 23, 2026) and its 1 other brand-application label do not name bupropion in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Haloperidol), PD-Rx Pharmaceuticals, Inc., effective April 23, 2026 (SPL set 533b0b4c-cbd6-4ec0-a333-8b04b5b43a1d), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Bupropion | Haloperidol | |
|---|---|---|
| Labeled for | Depression, Quitting smoking | Schizophrenia |
| Boxed warning | Yes | Yes |
| Pharmacy cost (NADAC) | $0.0785 per tablet 150 mg tablet | $15.60 per mL 100 mg/mL vial |
| Shortage now | No current entry | A presentation being discontinued |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once