What the FDA labels say about taking them together
Bupropion and fenfluramine
Fenfluramine's FDA label of October 27, 2025 names bupropion in its warnings and precautions section; the bupropion labels PlainMeds reads (4) do not name fenfluramine. The fenfluramine label: “… serotonin reuptake inhibitors (SSRIs), tricyclic antidepressants (TCAs), bupropion, triptans, dietary supplements, drugs that impair metabolism of serotonin (including monoamine oxidase inhibitors [MAOIs], which are …”
Check it at the source: the bupropion FDA label on DailyMed (effective June 21, 2024); the fenfluramine FDA label on DailyMed (effective October 27, 2025, UCB, Inc.).
What does the bupropion label say about fenfluramine?
Bupropion's label (effective June 21, 2024) and its 3 other brand-application labels do not name fenfluramine in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (BUPROPION HYDROCHLORIDE), Epic Pharma LLC, effective June 21, 2024 (SPL set 9fb44e96-6160-4a4a-90cb-91764c0dcd89), via openFDA; the full label on DailyMed
What does the fenfluramine label say about bupropion?
Fenfluramine label, warnings and precautionsSerotonin syndrome, a potentially life-threatening condition, may occur with FINTEPLA, particularly with concomitant administration of FINTEPLA with other serotonergic drugs, including, but not limited to, selective serotonin-norepinephrine reuptake inhibitors (SNRIs), selective serotonin reuptake inhibitors (SSRIs), tricyclic antidepressants (TCAs), bupropion, triptans, dietary supplements (e.g., St. John's Wort, tryptophan), drugs that impair metabolism of serotonin (including monoamine oxidase inhibitors [MAOIs], which are contraindicated with FINTEPLA [see Contraindications (4) ], dextromethorphan, lithium, tramadol, and antipsychotics with serotonergic agonist activity.
Source: FDA drug label (Fintepla), NDA212102 (Ucb Inc), as published by UCB, Inc., effective October 27, 2025 (SPL set e88f360e-33ad-4cd6-b2de-5ef885857c5d), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Bupropion | Fenfluramine | |
|---|---|---|
| Labeled for | Depression, Quitting smoking | n/a |
| Boxed warning | Yes | Yes |
| Pharmacy cost (NADAC) | $0.0785 per tablet 150 mg tablet | n/a |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once