What the FDA labels say about taking them together
Bupropion and cocaine
Bupropion's FDA label of June 21, 2024 names cocaine in its warnings and precautions section; the cocaine labels PlainMeds reads (2) do not name bupropion. The bupropion label: “… the seizure threshold, metabolic disorders, or use of illicit drugs (e.g., cocaine) or abuse or misuse of prescription drugs such as CNS stimulants.”
Check it at the source: the bupropion FDA label on DailyMed (effective June 21, 2024); the cocaine FDA label on DailyMed (effective January 12, 2026, OMNIVIUM PHARMACEUTICALS LLC.).
What does the bupropion label say about cocaine?
Bupropion label, warnings and precautionsCNS tumor or CNS infection; severe stroke; concomitant use of other medications that lower the seizure threshold (e.g., other bupropion products, antipsychotics, tricyclic antidepressants, theophylline, and systemic corticosteroids); metabolic disorders (e.g., hypoglycemia, hyponatremia, severe hepatic impairment, and hypoxia); use of illicit drugs (e.g., cocaine); or abuse or misuse of prescription drugs such as CNS stimulants.
Aplenzin label (Bausch Health US, LLC, March 4, 2026), warnings and precautionsThe following conditions can also increase the risk of seizure: concomitant use of other medications that lower the seizure threshold (e.g., other bupropion products, antipsychotics, tricyclic antidepressants, theophylline, and systemic corticosteroids), metabolic disorders (e.g., hypoglycemia, hyponatremia, severe hepatic impairment, and hypoxia), or use of illicit drugs (e.g., cocaine) or abuse or misuse of prescription drugs such as CNS stimulants.
Source: FDA drug label (Aplenzin, NDA022108), Bausch Health US, LLC, effective March 4, 2026 (SPL set 6494d2d9-0ce4-4126-b1c7-49684395942b), via openFDA
Source: FDA drug label (BUPROPION HYDROCHLORIDE), Epic Pharma LLC, effective June 21, 2024 (SPL set 9fb44e96-6160-4a4a-90cb-91764c0dcd89), via openFDA; the full label on DailyMed
What does the cocaine label say about bupropion?
Cocaine's label (effective January 12, 2026) and its 1 other brand-application label do not name bupropion in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (NUMBRINO), OMNIVIUM PHARMACEUTICALS LLC., effective January 12, 2026 (SPL set d724b5b4-6654-4bf5-9eed-e2c7943084ed), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Bupropion | Cocaine | |
|---|---|---|
| Labeled for | Depression, Quitting smoking | n/a |
| Boxed warning | Yes | Yes |
| Pharmacy cost (NADAC) | $0.0785 per tablet 150 mg tablet | n/a |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once