What the FDA labels say about taking them together
Bupivacaine/meloxicam and digoxin
Bupivacaine/meloxicam's FDA label of April 20, 2026 names digoxin in its drug interactions section; the digoxin labels PlainMeds reads (3) do not name bupivacaine/meloxicam. The bupivacaine/meloxicam label: “The concomitant use of NSAIDS with digoxin has been reported to increase the serum concentration and prolong the half-life of digoxin.”
Check it at the source: the bupivacaine/meloxicam FDA label on DailyMed (effective April 20, 2026, Heron Therapeutics, Inc.); the digoxin FDA label on DailyMed (effective December 5, 2024, Advanz Pharma (US) Corp.).
What does the bupivacaine/meloxicam label say about digoxin?
Bupivacaine/meloxicam label, drug interactionsClinical Impact: The concomitant use of NSAIDS with digoxin has been reported to increase the serum concentration and prolong the half-life of digoxin. Intervention: During concomitant use of ZYNRELEF and digoxin, monitor serum digoxin levels.
Source: FDA drug label (ZYNRELEF), Heron Therapeutics, Inc., effective April 20, 2026 (SPL set dab484a7-9353-43ba-9e74-7fab910c712b), via openFDA; the full label on DailyMed
What does the digoxin label say about bupivacaine/meloxicam?
Digoxin's label (effective December 5, 2024) and its 2 other brand-application labels do not name bupivacaine/meloxicam in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (LANOXIN), Advanz Pharma (US) Corp., effective December 5, 2024 (SPL set d91e3646-4c63-4512-ab22-db39c085c4dc), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Bupivacaine/meloxicam | Digoxin | |
|---|---|---|
| Labeled for | n/a | Heart failure, Atrial fibrillation |
| Boxed warning | Yes | No |
| Pharmacy cost (NADAC) | n/a | $0.133 per tablet 125 mcg tablet |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once