What the FDA labels say about taking them together
Bromocriptine and probenecid
Bromocriptine's FDA label (Cycloset) of January 12, 2026 names probenecid in its drug interactions section; the probenecid label PlainMeds reads does not name bromocriptine. The bromocriptine label: “Therefore, CYCLOSET may increase the unbound fraction of other concomitantly used highly protein-bound therapies, which may alter their effectiveness and risk for side effects.”
Check it at the source: the bromocriptine FDA label on DailyMed (effective July 27, 2026, ANI Pharmaceuticals, Inc.); the probenecid FDA label on DailyMed (effective January 5, 2021, Lannett Company, Inc.).
What does the bromocriptine label say about probenecid?
Cycloset label (Avvisto Therapeutics LLC, January 12, 2026), drug interactionsTherefore, CYCLOSET may increase the unbound fraction of other concomitantly used highly protein-bound therapies (e.g., salicylates, sulfonamides, chloramphenicol and probenecid), which may alter their effectiveness and risk for side effects.
Source: FDA drug label (Cycloset, NDA020866), Avvisto Therapeutics LLC, effective January 12, 2026 (SPL set e42ba916-16b9-4d1c-8d09-9d2fbb1b6c20), via openFDA
Source: FDA drug label (Bromocriptine Mesylate), ANI Pharmaceuticals, Inc., effective July 27, 2026 (SPL set 17f3a343-1782-4799-95ba-31dfe93be2cf), via openFDA; the full label on DailyMed
What does the probenecid label say about bromocriptine?
Probenecid's label (effective January 5, 2021) does not name bromocriptine in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Probenecid), Lannett Company, Inc., effective January 5, 2021 (SPL set ab497fd8-00c3-4364-b003-b39d21fbdf38), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Bromocriptine | Probenecid | |
|---|---|---|
| Labeled for | Parkinson's disease, Type 2 diabetes | Gout |
| Boxed warning | No | No |
| Pharmacy cost (NADAC) | $1.61 per tablet 2.5 mg tablet | $0.636 per tablet 500 mg tablet |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once