What the FDA labels say about taking them together
Brexpiprazole and olanzapine
Brexpiprazole's FDA label of May 6, 2026 names olanzapine in its warnings and precautions section; olanzapine's label does not name brexpiprazole itself but warns about its class (Atypical antipsychotics).
Check it at the source: the brexpiprazole FDA label on DailyMed (effective May 6, 2026, Otsuka America Pharmaceutical, Inc.); the olanzapine FDA label on DailyMed (effective March 5, 2026, Macleods Pharmaceuticals Limited).
What does the brexpiprazole label say about olanzapine?
Brexpiprazole label, warnings and precautionsStroke in Elderly Patients with Dementia-Related Psychosis In placebo-controlled trials in elderly patients with dementia, patients randomized to risperidone, aripiprazole, and olanzapine had a higher incidence of stroke and transient ischemic attack, including fatal stroke.
Source: FDA drug label (Rexulti), Otsuka America Pharmaceutical, Inc., effective May 6, 2026 (SPL set 2d301358-6291-4ec1-bd87-37b4ad9bd850), via openFDA; the full label on DailyMed
What does the olanzapine label say about brexpiprazole?
Olanzapine's label does not name brexpiprazole itself; it warns about its class (Atypical antipsychotics):
Olanzapine label, boxed warningAnalyses of seventeen placebo-controlled trials (modal duration of 10 weeks), largely in patients taking atypical antipsychotic drugs, revealed a risk of death in drug-treated patients of between 1.6 to 1.7 times the risk of death in placebo-treated patients.
Olanzapine label, boxed warningINCREASED MORTALITY IN ELDERLY PATIENTS WITH DEMENTIA-RELATED PSYCHOSIS Elderly patients with dementia-related psychosis treated with antipsychotic drugs are at an increased risk of death.
Source: FDA drug label (Olanzapine), Macleods Pharmaceuticals Limited, effective March 5, 2026 (SPL set 8e095987-bdea-42f2-9550-c7155cf07d30), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Brexpiprazole | Olanzapine | |
|---|---|---|
| Labeled for | Depression, Schizophrenia | Schizophrenia, Bipolar disorder, Depression |
| Boxed warning | Yes | Yes |
| Pharmacy cost (NADAC) | $49.50 per tablet 0.25 mg tablet | $0.147 per tablet 20 mg tablet |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once