What the FDA labels say about taking them together
Bremelanotide and naltrexone
Bremelanotide's FDA label of November 13, 2025 names naltrexone in its drug interactions section; the naltrexone labels PlainMeds reads (2) do not name bremelanotide. The bremelanotide label: “… VYLEESI may significantly decrease the systemic exposure of orally-administered naltrexone; avoid use with orally administered naltrexone-containing products intended to treat alcohol or opioid addiction.”
Check it at the source: the bremelanotide FDA label on DailyMed (effective November 13, 2025, Cosette Pharmaceuticals, Inc.); the naltrexone FDA label on DailyMed (effective September 4, 2026).
What does the bremelanotide label say about naltrexone?
Bremelanotide label, drug interactionsDRUG INTERACTIONS VYLEESI may slow gastric emptying and impact absorption of concomitantly administered oral medications. ( 7.1 ) VYLEESI may significantly decrease the systemic exposure of orally-administered naltrexone; avoid use with orally administered naltrexone-containing products intended to treat alcohol or opioid addiction.
Source: FDA drug label (Vyleesi), Cosette Pharmaceuticals, Inc., effective November 13, 2025 (SPL set f1d0c1b5-2f39-4bad-a6a4-0066e3ad5dcf), via openFDA; the full label on DailyMed
What does the naltrexone label say about bremelanotide?
Naltrexone's label (effective September 4, 2026) and its 1 other brand-application label do not name bremelanotide in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (NALTREXONE HYDROCHLORIDE), SpecGx LLC, effective September 4, 2026 (SPL set 06ff2d5a-e62b-4fa4-bbdb-01938535bc65), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Bremelanotide | Naltrexone | |
|---|---|---|
| Labeled for | n/a | Alcohol use disorder, Opioid use disorder |
| Boxed warning | No | No |
| Pharmacy cost (NADAC) | n/a | $1.14 per tablet 50 mg tablet |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once