What the FDA labels say about taking them together
Bosentan and nelfinavir
Nelfinavir's FDA label of December 11, 2025 names bosentan in its drug interactions section; the bosentan label PlainMeds reads does not name nelfinavir. The nelfinavir label: “Concentrations of bosentan may be increased when coadministered with VIRACEPT. Coadministration of bosentan in patients on VIRACEPT or coadministration of VIRACEPT in patients on bosentan: Start at or adjust bosentan to …”
Check it at the source: the bosentan FDA label on DailyMed (effective November 17, 2025, Actelion Pharmaceuticals US, Inc.); the nelfinavir FDA label on DailyMed (effective December 11, 2025, AGOURON).
What does the bosentan label say about nelfinavir?
Bosentan's label (effective November 17, 2025) does not name nelfinavir in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Tracleer), Actelion Pharmaceuticals US, Inc., effective November 17, 2025 (SPL set 749e42fb-2fe0-45dd-9268-b43bb3f4081c), via openFDA; the full label on DailyMed
What does the nelfinavir label say about bosentan?
Nelfinavir label, drug interactionsConcomitant Drug Class/Drug Name: Bosentan; Effect on Concentration: ↑ bosentan; Clinical Comment: Concentrations of bosentan may be increased when coadministered with VIRACEPT. Coadministration of bosentan in patients on VIRACEPT or coadministration of VIRACEPT in patients on bosentan: Start at or adjust bosentan to 62.5 mg once daily or every other day based upon individual tolerability.
Source: FDA drug label (VIRACEPT), AGOURON, effective December 11, 2025 (SPL set e72c2bc6-9462-4a2e-8e1d-b97592376cbd), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Bosentan | Nelfinavir | |
|---|---|---|
| Labeled for | Pulmonary arterial hypertension | HIV |
| Boxed warning | Yes | No |
| Pharmacy cost (NADAC) | n/a | n/a |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once