What the FDA labels say about taking them together
Bisoprolol and diltiazem
Bisoprolol's FDA label of March 11, 2026 names diltiazem in its drug interactions section; diltiazem's label does not name bisoprolol itself but warns about its class (Beta blockers).
Check it at the source: the bisoprolol FDA label on DailyMed (effective March 11, 2026, Micro Labs Limited); the diltiazem FDA label on DailyMed (effective August 7, 2026, Bausch Health US, LLC).
What does the bisoprolol label say about diltiazem?
Bisoprolol label, drug interactionsBisoprolol fumarate should be used with care when myocardial depressants or inhibitors of AV conduction, such as certain calcium antagonists (particularly of the phenylalkylamine [verapamil] and benzothiazepine [diltiazem] classes), or antiarrhythmic agents, such as disopyramide, are used concurrently.
Source: FDA drug label (Bisoprolol), Micro Labs Limited, effective March 11, 2026 (SPL set c3ee566c-74c4-45f4-a947-526a7313e326), via openFDA; the full label on DailyMed
What does the diltiazem label say about bisoprolol?
Diltiazem's label does not name bisoprolol itself; it warns about its class (Beta blockers):
Diltiazem label, drug interactionsBeta-blockers, digitalis, and other agents known to impair cardiac contractility and conduction may increase risk for hypotension, bradycardia, and heart failure.
Diltiazem label, drug interactionsPharmacologic studies indicate that there may be additive effects in prolonging AV conduction when using beta-blockers or digitalis concomitantly with Tiazac (see WARNINGS ).
Source: FDA drug label (TIAZAC EXTENDED RELEASE), Bausch Health US, LLC, effective August 7, 2026 (SPL set c567fe7e-887e-4291-a0d1-2dd3f25cbf25), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Bisoprolol | Diltiazem | |
|---|---|---|
| Labeled for | High blood pressure | High blood pressure, Angina, Atrial fibrillation |
| Boxed warning | No | No |
| Pharmacy cost (NADAC) | $0.114 per tablet 5 mg tablet | $0.144 per capsule 24h ER(cd) 120 mg capsule |
| Shortage now | No current entry | A presentation being discontinued |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once