What the FDA labels say about taking them together
Bismuth subsalicylate and sarecycline
Sarecycline's FDA label of June 5, 2024 names bismuth subsalicylate in its drug interactions section; the bismuth subsalicylate label PlainMeds reads does not name sarecycline. The sarecycline label: “Antacids and Iron Preparations Coadministration with antacids containing aluminum, calcium or magnesium, bismuth subsalicylate, and iron-containing preparations may impair absorption of SEYSARA, similar to other …”
Check it at the source: the bismuth subsalicylate FDA label on DailyMed (effective October 3, 2023); the sarecycline FDA label on DailyMed (effective June 5, 2024, Almirall, LLC).
What does the bismuth subsalicylate label say about sarecycline?
Bismuth subsalicylate's label (effective October 3, 2023) does not name sarecycline in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Pepto-Bismol Chewable, TRAVEL BASIX), Lil' Drug Store Products, Inc., effective October 3, 2023 (SPL set dd2f2205-34d1-4960-bf37-bb8d534cd0e1), via openFDA; the full label on DailyMed
What does the sarecycline label say about bismuth subsalicylate?
Sarecycline label, drug interactionsAntacids and Iron Preparations Coadministration with antacids containing aluminum, calcium or magnesium, bismuth subsalicylate, and iron-containing preparations may impair absorption of SEYSARA, similar to other tetracyclines, which may decrease its efficacy.
Source: FDA drug label (Seysara), Almirall, LLC, effective June 5, 2024 (SPL set b200957c-3004-4988-be97-9fd619a83649), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Bismuth subsalicylate | Sarecycline | |
|---|---|---|
| Labeled for | Diarrhea, Acid reflux and ulcers, Nausea and vomiting | n/a |
| Boxed warning | No | No |
| Pharmacy cost (NADAC) | $0.0817 per tablet 262 mg tablet chewable | n/a |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once