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What the FDA labels say about taking them together

Bimekizumab and warfarin

Bimekizumab's FDA label of June 16, 2025 names warfarin in its drug interactions section; the warfarin label PlainMeds reads does not name bimekizumab. The bimekizumab label: “… with a narrow therapeutic index, consider monitoring for effect (e.g., for warfarin) or drug concentration (e.g., for cyclosporine) and consider dosage modification of the CYP450 substrate.”

Check it at the source: the bimekizumab FDA label on DailyMed (effective June 16, 2025); the warfarin FDA label on DailyMed (effective May 29, 2026, Amneal Pharmaceuticals LLC).

What does the bimekizumab label say about warfarin?

Bimekizumab label, drug interactions

Therefore, upon initiation or discontinuation of BIMZELX in patients who are receiving concomitant drugs which are CYP450 substrates, particularly those with a narrow therapeutic index, consider monitoring for effect (e.g., for warfarin) or drug concentration (e.g., for cyclosporine) and consider dosage modification of the CYP450 substrate.

Source: FDA drug label (Bimzelx), UCB, Inc., effective June 16, 2025 (SPL set 26b88358-871f-4c80-9d80-b2fb16477f81), via openFDA; the full label on DailyMed

What does the warfarin label say about bimekizumab?

Warfarin's label (effective May 29, 2026) does not name bimekizumab in these sections. A label lists what its studies and reports found; it is not a complete list.

Source: FDA drug label (Warfarin Sodium), Amneal Pharmaceuticals LLC, effective May 29, 2026 (SPL set 558b7a0d-5490-4c1b-802e-3ab3f1efe760), via openFDA; the full label on DailyMed

These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.

Both medicines on the record

0Bimekizumab generic labelers
19Warfarin generic labelers
BimekizumabWarfarin
Labeled forPsoriasisBlood clots (DVT and PE), Atrial fibrillation
Boxed warningNoYes
Pharmacy cost (NADAC)$8,073.83 per mL 160 mg/mL autoinjector$0.093 per tablet 2 mg tablet
Shortage nowNo current entryNo current entry

Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)

What next?