What the FDA labels say about taking them together
Betamethasone and cobicistat
Cobicistat's FDA label of February 10, 2026 names betamethasone in its drug interactions section; the betamethasone labels PlainMeds reads (4) do not name cobicistat. The cobicistat label: “Coadministration with oral dexamethasone or other systemic corticosteroids that induce CYP3A may result in loss of therapeutic effect and development of resistance to atazanavir or darunavir. …”
Check it at the source: the betamethasone FDA label on DailyMed (effective January 28, 2026, E. Fougera & Co. a division of Fougera Pharmaceuticals, LLC); the cobicistat FDA label on DailyMed (effective February 10, 2026, Gilead Sciences, Inc.).
What does the betamethasone label say about cobicistat?
Betamethasone's label (effective January 28, 2026) and its 3 other brand-application labels do not name cobicistat in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Betamethasone Valerate), E. Fougera & Co. a division of Fougera Pharmaceuticals, LLC, effective January 28, 2026 (SPL set 0b386ccc-a2d4-4d18-a2d7-e46ff894c674), via openFDA; the full label on DailyMed
What does the cobicistat label say about betamethasone?
Cobicistat label, drug interactionsConcomitant Drug Class/Drug Name: Corticosteroids: e.g., betamethasone budesonide ciclesonide dexamethasone fluticasone methylprednisolone mometasone triamcinolone; Potential Effect ↑ = Increase, ↓ = Decrease, ↔ = No change: ↓ cobicistat ↓ atazanavir ↓ darunavir ↑ corticosteroids; Clinical Comment: Coadministration with oral dexamethasone or other systemic corticosteroids that induce CYP3A may result in loss of therapeutic effect and development of resistance to atazanavir or darunavir. Consider alternative corticosteroids. …
Source: FDA drug label (Tybost), Gilead Sciences, Inc., effective February 10, 2026 (SPL set 3784c35c-e87f-410c-900b-8fd6313c6010), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Betamethasone | Cobicistat | |
|---|---|---|
| Labeled for | Asthma, Eczema (atopic dermatitis), Anemia, Leukemia, lymphoma and myeloma, Multiple sclerosis, Psoriasis | HIV |
| Boxed warning | No | No |
| Pharmacy cost (NADAC) | $0.418 per gram 0.05% cream | n/a |
| Shortage now | No current entry | A presentation being discontinued |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once