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What the FDA labels say about taking them together

Benzalkonium and latanoprost

Latanoprost's FDA label (Xalatan) of May 15, 2023 names benzalkonium in its contraindications section; the benzalkonium label PlainMeds reads does not name latanoprost.

Check it at the source: the benzalkonium FDA label on DailyMed (effective November 19, 2025); the latanoprost FDA label on DailyMed (effective December 18, 2025, Sun Pharmaceutical Industries, Inc.).

What does the benzalkonium label say about latanoprost?

Benzalkonium's label (effective November 19, 2025) does not name latanoprost in these sections. A label lists what its studies and reports found; it is not a complete list.

Source: FDA drug label (Dial Antibacterial Hydrating Coconut Milk), Henkel Corporation, effective November 19, 2025 (SPL set 43f9be89-b434-75da-e063-6294a90a1864), via openFDA; the full label on DailyMed

What does the latanoprost label say about benzalkonium?

Xalatan label (Viatris Specialty LLC, May 15, 2023), contraindications

CONTRAINDICATIONS Known hypersensitivity to latanoprost, benzalkonium chloride, or any other ingredients in this product.

Xalatan label (Viatris Specialty LLC, May 15, 2023), warnings and precautions

Contact Lens Use XALATAN contains benzalkonium chloride, which may be absorbed by contact lenses.

Source: FDA drug label (Xalatan, NDA020597), Viatris Specialty LLC, effective May 15, 2023 (SPL set a98595b3-9f47-48e0-b18d-550a2095f264), via openFDA

Source: FDA drug label (XELPROS), Sun Pharmaceutical Industries, Inc., effective December 18, 2025 (SPL set 34ad5cf6-4df0-4104-bddd-4c7631133ded), via openFDA; the full label on DailyMed

These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.

Both medicines on the record

0Benzalkonium generic labelers
14Latanoprost generic labelers
BenzalkoniumLatanoprost
Labeled forn/aGlaucoma
Boxed warningNoNo
Pharmacy cost (NADAC)n/a$1.58 per mL 0.005% eye drops
Shortage nowNo current entryNo current entry

Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)

What next?