What the FDA labels say about taking them together
Benazepril/hydrochlorothiazide and digoxin
Benazepril/hydrochlorothiazide's FDA label of February 24, 2026 names digoxin in its drug interactions section; the digoxin labels PlainMeds reads (3) do not name benazepril/hydrochlorothiazide. The benazepril/hydrochlorothiazide label: “Digitalis glycosides: Thiazide-induced hypokalemia or hypomagnesemia may predispose the patients to digoxin toxicity Skeletal muscle relaxants:”
Check it at the source: the benazepril/hydrochlorothiazide FDA label on DailyMed (effective February 24, 2026, Validus Pharmaceuticals LLC); the digoxin FDA label on DailyMed (effective December 5, 2024, Advanz Pharma (US) Corp.).
What does the benazepril/hydrochlorothiazide label say about digoxin?
Benazepril/hydrochlorothiazide label, drug interactionsDigitalis glycosides: Thiazide-induced hypokalemia or hypomagnesemia may predispose the patients to digoxin toxicity Skeletal muscle relaxants:
Source: FDA drug label (Lotensin HCT), Validus Pharmaceuticals LLC, effective February 24, 2026 (SPL set 94c4536f-e28e-48b1-8336-b3939917e99d), via openFDA; the full label on DailyMed
What does the digoxin label say about benazepril/hydrochlorothiazide?
Digoxin's label (effective December 5, 2024) and its 2 other brand-application labels do not name benazepril/hydrochlorothiazide in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (LANOXIN), Advanz Pharma (US) Corp., effective December 5, 2024 (SPL set d91e3646-4c63-4512-ab22-db39c085c4dc), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Benazepril/hydrochlorothiazide | Digoxin | |
|---|---|---|
| Labeled for | High blood pressure | Heart failure, Atrial fibrillation |
| Boxed warning | Yes | No |
| Pharmacy cost (NADAC) | $0.222 per tablet 20-12.5 mg tablet | $0.133 per tablet 125 mcg tablet |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once