What the FDA labels say about taking them together
Azithromycin and nelfinavir
Azithromycin's FDA label of December 4, 2025 names nelfinavir in its drug interactions section, and nelfinavir's label names azithromycin too. The nelfinavir label: “Dose adjustment of azithromycin is not recommended, but close monitoring for known side effects such as liver enzyme abnormalities and hearing impairment is warranted.”
Check it at the source: the azithromycin FDA label on DailyMed (effective December 4, 2025, Bionpharma Inc.); the nelfinavir FDA label on DailyMed (effective December 11, 2025, AGOURON).
What does the azithromycin label say about nelfinavir?
Azithromycin label, drug interactionsDRUG INTERACTIONS Nelfinavir: Close monitoring for known adverse reactions of azithromycin, such as liver enzyme abnormalities and hearing impairment, is warranted.
Zithromax label (Pfizer Laboratories Div Pfizer Inc, July 24, 2026), drug interactionsNelfinavir Co-administration of nelfinavir at steady-state with a single oral dose of azithromycin resulted in increased azithromycin serum concentrations.
Source: FDA drug label (Zithromax, NDA050711), Pfizer Laboratories Div Pfizer Inc, effective July 24, 2026 (SPL set db52b91e-79f7-4cc1-9564-f2eee8e31c45), via openFDA
Source: FDA drug label (Azithromycin), Bionpharma Inc., effective December 4, 2025 (SPL set 859bb02c-a4bc-46fa-9fc9-def1219b5dfb), via openFDA; the full label on DailyMed
What does the nelfinavir label say about azithromycin?
Nelfinavir label, drug interactionsConcomitant Drug Class/Drug Name: Azithromycin; Effect on Concentration: ↑ azithromycin; Clinical Comment: Dose adjustment of azithromycin is not recommended, but close monitoring for known side effects such as liver enzyme abnormalities and hearing impairment is warranted.
Source: FDA drug label (VIRACEPT), AGOURON, effective December 11, 2025 (SPL set e72c2bc6-9462-4a2e-8e1d-b97592376cbd), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Azithromycin | Nelfinavir | |
|---|---|---|
| Labeled for | Bacterial infections | HIV |
| Boxed warning | No | No |
| Pharmacy cost (NADAC) | $0.266 per tablet 250 mg tablet | n/a |
| Shortage now | A presentation being discontinued | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once