What the FDA labels say about taking them together
Avutometinib/defactinib and warfarin
Avutometinib/defactinib's FDA label of May 1, 2025 names warfarin in its drug interactions section; the warfarin label PlainMeds reads does not name avutometinib/defactinib. The avutometinib/defactinib label: “Avoid concomitant use with AVMAPKI FAKZYNJA CO-PACK. Warfarin: Avoid concomitant use of AVMAPKI FAKZYNJA CO-PACK with warfarin and use an alternative to warfarin. Gastric acid reducing agents:”
Check it at the source: the avutometinib/defactinib FDA label on DailyMed (effective May 1, 2025, Verastem Inc.); the warfarin FDA label on DailyMed (effective May 29, 2026, Amneal Pharmaceuticals LLC).
What does the avutometinib/defactinib label say about warfarin?
Avutometinib/defactinib label, drug interactionsAvoid concomitant use with AVMAPKI FAKZYNJA CO-PACK. ( 7.1 ) Warfarin: Avoid concomitant use of AVMAPKI FAKZYNJA CO-PACK with warfarin and use an alternative to warfarin. ( 7.2 ) Gastric acid reducing agents:
Source: FDA drug label (AVMAPKI FAKZYNJA CO-PACK), Verastem Inc., effective May 1, 2025 (SPL set 65889527-1406-45df-8a85-e2690dcf427d), via openFDA; the full label on DailyMed
What does the warfarin label say about avutometinib/defactinib?
Warfarin's label (effective May 29, 2026) does not name avutometinib/defactinib in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Warfarin Sodium), Amneal Pharmaceuticals LLC, effective May 29, 2026 (SPL set 558b7a0d-5490-4c1b-802e-3ab3f1efe760), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Avutometinib/defactinib | Warfarin | |
|---|---|---|
| Labeled for | n/a | Blood clots (DVT and PE), Atrial fibrillation |
| Boxed warning | No | Yes |
| Pharmacy cost (NADAC) | n/a | $0.093 per tablet 2 mg tablet |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once