What the FDA labels say about taking them together
Avanafil and nitric oxide
Avanafil's FDA label of December 17, 2025 names nitric oxide in its contraindications section; the nitric oxide labels PlainMeds reads (2) do not name avanafil.
Check it at the source: the avanafil FDA label on DailyMed (effective December 17, 2025, Camber Pharmaceuticals, Inc.); the nitric oxide FDA label on DailyMed (effective December 11, 2025, VERO BIOTECH, INC.).
What does the avanafil label say about nitric oxide?
Avanafil label, contraindicationsConsistent with its known effects on the nitric oxide/cyclic guanosine monophosphate (cGMP) pathway, avanafil has been shown to potentiate the hypotensive effects of nitrates.
Avanafil label, warnings and precautionsIn vitro studies with human platelets indicate that avanafil potentiates the anti-aggregatory effect of sodium nitroprusside (a nitric oxide [NO] donor).
Source: FDA drug label (Avanafil), ANDA209266 (Hetero Labs Ltd V), as published by Camber Pharmaceuticals, Inc., effective December 17, 2025 (SPL set 1d04e17d-7399-430a-a8bb-fa1912b155e9), via openFDA; the full label on DailyMed
What does the nitric oxide label say about avanafil?
Nitric oxide's label (effective December 11, 2025) and its 1 other brand-application label do not name avanafil in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (GENOSYL), VERO BIOTECH, INC., effective December 11, 2025 (SPL set c9560c54-9e28-4039-a4e5-5000c41c6c85), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Avanafil | Nitric oxide | |
|---|---|---|
| Labeled for | Erectile dysfunction | n/a |
| Boxed warning | No | No |
| Pharmacy cost (NADAC) | $50.00 per tablet 200 mg tablet | n/a |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once