What the FDA labels say about taking them together
Avanafil and enalapril
Avanafil's FDA label of December 17, 2025 names enalapril in its drug interactions section; the enalapril labels PlainMeds reads (2) do not name avanafil.
Check it at the source: the avanafil FDA label on DailyMed (effective December 17, 2025, Camber Pharmaceuticals, Inc.); the enalapril FDA label on DailyMed (effective January 23, 2026, Bausch Health US LLC).
What does the avanafil label say about enalapril?
Avanafil label, drug interactionsA clinical pharmacology trial was conducted to assess the effect of avanafil on the potentiation of the blood pressure-lowering effects of selected antihypertensive medications (amlodipine and enalapril).
Source: FDA drug label (Avanafil), ANDA209266 (Hetero Labs Ltd V), as published by Camber Pharmaceuticals, Inc., effective December 17, 2025 (SPL set 1d04e17d-7399-430a-a8bb-fa1912b155e9), via openFDA; the full label on DailyMed
What does the enalapril label say about avanafil?
Enalapril's label (effective January 23, 2026) and its 1 other brand-application label do not name avanafil in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Vasotec), Bausch Health US LLC, effective January 23, 2026 (SPL set 39631f1f-5d19-43c1-b504-bf56d991ed97), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Avanafil | Enalapril | |
|---|---|---|
| Labeled for | Erectile dysfunction | High blood pressure, Heart failure |
| Boxed warning | No | Yes |
| Pharmacy cost (NADAC) | $50.00 per tablet 200 mg tablet | $0.0664 per tablet 10 mg tablet |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once