What the FDA labels say about taking them together
Auranofin and phenytoin
Auranofin's FDA label of November 8, 2025 names phenytoin in its drug interactions section; the phenytoin labels PlainMeds reads (2) do not name auranofin. The auranofin label: “Drug Interactions: In a single patient-report, there is the suggestion that concurrent administration of RIDAURA and phenytoin may have increased phenytoin blood levels.”
Check it at the source: the auranofin FDA label on DailyMed (effective November 8, 2025, Sebela Pharmaceuticals Inc.); the phenytoin FDA label on DailyMed (effective October 15, 2024, Mylan Pharmaceuticals Inc.).
What does the auranofin label say about phenytoin?
Auranofin label, drug interactionsDrug Interactions: In a single patient-report, there is the suggestion that concurrent administration of RIDAURA and phenytoin may have increased phenytoin blood levels.
Source: FDA drug label (RIDAURA), NDA018689 (Legacy), as published by Sebela Pharmaceuticals Inc., effective November 8, 2025 (SPL set 43ba3de1-ab2e-06f6-e054-00144ff8d46c), via openFDA; the full label on DailyMed
What does the phenytoin label say about auranofin?
Phenytoin's label (effective October 15, 2024) and its 1 other brand-application label do not name auranofin in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Phenytek), Mylan Pharmaceuticals Inc., effective October 15, 2024 (SPL set 0f94c791-8b07-4b41-927e-c9f28bec5f60), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Auranofin | Phenytoin | |
|---|---|---|
| Labeled for | Rheumatoid arthritis | Seizures and epilepsy |
| Boxed warning | Yes | No |
| Pharmacy cost (NADAC) | $24.85 per capsule 3 mg capsule | $0.145 per capsule 100 mg capsule |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once