What the FDA labels say about taking them together
Atovaquone and tetracycline
Atovaquone's FDA label of March 20, 2026 names tetracycline in its drug interactions section; the tetracycline label PlainMeds reads does not name atovaquone. The atovaquone label: “Concomitant administration of tetracycline reduces atovaquone concentrations; use caution when coadministering.”
Check it at the source: the atovaquone FDA label on DailyMed (effective March 20, 2026); the tetracycline FDA label on DailyMed (effective March 18, 2025, Heritage Pharmaceuticals Inc. d/b/a Avet Pharmaceuticals Inc.).
What does the atovaquone label say about tetracycline?
Atovaquone label, drug interactionsConcomitant administration of tetracycline reduces atovaquone concentrations; use caution when coadministering.
Source: FDA drug label (MEPRON), GlaxoSmithKline LLC, effective March 20, 2026 (SPL set b426b6bf-f07e-4580-97ae-dfca1ddf5b8f), via openFDA; the full label on DailyMed
What does the tetracycline label say about atovaquone?
Tetracycline's label (effective March 18, 2025) does not name atovaquone in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (tetracycline hydrochloride), Heritage Pharmaceuticals Inc. d/b/a Avet Pharmaceuticals Inc., effective March 18, 2025 (SPL set eaa5b1bd-0927-46e4-b941-32fcc492d258), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Atovaquone | Tetracycline | |
|---|---|---|
| Labeled for | n/a | Bacterial infections |
| Boxed warning | No | No |
| Pharmacy cost (NADAC) | $0.767 per mL 750 mg/5 mL suspension | $0.247 per capsule 250 mg capsule |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once