What the FDA labels say about taking them together
Atorvastatin and digoxin
Atorvastatin's FDA label of April 15, 2024 names digoxin in its drug interactions section; the digoxin labels PlainMeds reads (3) do not name atorvastatin. The atorvastatin label: “May increase digoxin plasma levels; monitor patients appropriately.”
Check it at the source: the atorvastatin FDA label on DailyMed (effective April 15, 2024, Viatris Specialty LLC); the digoxin FDA label on DailyMed (effective December 5, 2024, Advanz Pharma (US) Corp.).
What does the atorvastatin label say about digoxin?
Atorvastatin label, drug interactionsMay increase digoxin plasma levels; monitor patients appropriately ( 7.3 ).
Source: FDA drug label (Lipitor), NDA020702 (Upjohn), as published by Viatris Specialty LLC, effective April 15, 2024 (SPL set a60cc18b-0631-4cf0-b021-9f52224ece65), via openFDA; the full label on DailyMed
What does the digoxin label say about atorvastatin?
Digoxin's label (effective December 5, 2024) and its 2 other brand-application labels do not name atorvastatin in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (LANOXIN), Advanz Pharma (US) Corp., effective December 5, 2024 (SPL set d91e3646-4c63-4512-ab22-db39c085c4dc), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Atorvastatin | Digoxin | |
|---|---|---|
| Labeled for | High cholesterol, Angina, High triglycerides, Heart attack and coronary artery disease | Heart failure, Atrial fibrillation |
| Boxed warning | No | No |
| Pharmacy cost (NADAC) | $0.0228 per tablet 10 mg tablet | $0.133 per tablet 125 mcg tablet |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once