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What the FDA labels say about taking them together

Atenolol and disopyramide

Atenolol's FDA label of September 18, 2025 names disopyramide in its drug interactions section; the disopyramide label PlainMeds reads does not name atenolol.

Check it at the source: the atenolol FDA label on DailyMed (effective September 18, 2025, Upsher-Smith Laboratories, LLC); the disopyramide FDA label on DailyMed (effective August 24, 2026, Pfizer Laboratories Div Pfizer Inc).

What does the atenolol label say about disopyramide?

Atenolol label, drug interactions

Disopyramide has been associated with severe bradycardia, asystole and heart failure when administered with beta-blockers.

Source: FDA drug label (TENORMIN), NDA018240 (Twi Pharms), as published by Upsher-Smith Laboratories, LLC, effective September 18, 2025 (SPL set 6e850b1e-28a4-4ff8-8ed7-bb0b29faa28a), via openFDA; the full label on DailyMed

What does the disopyramide label say about atenolol?

Disopyramide's label (effective August 24, 2026) does not name atenolol in these sections. A label lists what its studies and reports found; it is not a complete list.

Source: FDA drug label (Norpace), Pfizer Laboratories Div Pfizer Inc, effective August 24, 2026 (SPL set e2aa1642-d262-4520-bc6a-9fd3ad795677), via openFDA; the full label on DailyMed

These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.

Both medicines on the record

35Atenolol generic labelers
2Disopyramide generic labelers
AtenololDisopyramide
Labeled forHigh blood pressure, Angina, Heart attack and coronary artery diseasen/a
Boxed warningNoYes
Pharmacy cost (NADAC)$0.0217 per tablet 25 mg tablet$0.801 per capsule 100 mg capsule
Shortage nowNo current entryA presentation being discontinued

Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)

What next?