What the FDA labels say about taking them together
Aspirin/oxycodone and warfarin
Aspirin/oxycodone's FDA label of December 17, 2025 names warfarin in its drug interactions section; warfarin's label does not name aspirin/oxycodone itself but warns about its class (NSAIDs (nonsteroidal anti-inflammatory drugs), Opioids (opioid agonists), platelet aggregation inhibitors). The aspirin/oxycodone label: “Anticoagulant Therapy (Heparin and Warfarin): Patients on anticoagulation therapy are at increased risk for bleeding because of drug-drug interactions and the effect on platelets.”
Check it at the source: the aspirin/oxycodone FDA label on DailyMed (effective December 17, 2025, Epic Pharma, LLC); the warfarin FDA label on DailyMed (effective May 29, 2026, Amneal Pharmaceuticals LLC).
What does the aspirin/oxycodone label say about warfarin?
Aspirin/oxycodone label, drug interactionsAnticoagulant Therapy (Heparin and Warfarin): Patients on anticoagulation therapy are at increased risk for bleeding because of drug-drug interactions and the effect on platelets.
Source: FDA drug label (Oxycodone and Aspirin), Epic Pharma, LLC, effective December 17, 2025 (SPL set 3292a7c6-5ba3-4563-bc62-e43040634123), via openFDA; the full label on DailyMed
What does the warfarin label say about aspirin/oxycodone?
Warfarin's label does not name aspirin/oxycodone itself; it warns about its class (NSAIDs (nonsteroidal anti-inflammatory drugs), Opioids (opioid agonists), platelet aggregation inhibitors):
Warfarin label, drug interactionsDrugs that Can Increase the Risk of Bleeding Drug Class Specific Drugs Anticoagulants argatroban, dabigatran, bivalirudin, desirudin, heparin, lepirudin Antiplatelet Agents aspirin, cilostazol, clopidogrel, dipyridamole, prasugrel, ticlopidine Nonsteroidal Anti-Inflammatory Agents celecoxib, diclofenac, diflunisal, fenoprofen, ibuprofen, indomethacin, ketoprofen, ketorolac, mefenamic acid, naproxen, oxaprozin, piroxicam, sulindac Serotonin Reuptake Inhibitors citalopram, desvenlafaxine, duloxetine, escitalopram …
Source: FDA drug label (Warfarin Sodium), Amneal Pharmaceuticals LLC, effective May 29, 2026 (SPL set 558b7a0d-5490-4c1b-802e-3ab3f1efe760), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Aspirin/oxycodone | Warfarin | |
|---|---|---|
| Labeled for | Pain | Blood clots (DVT and PE), Atrial fibrillation |
| Boxed warning | Yes | Yes |
| Pharmacy cost (NADAC) | n/a | $0.093 per tablet 2 mg tablet |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once