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What the FDA labels say about taking them together

Aspirin/dipyridamole and warfarin

Aspirin/dipyridamole's FDA label of January 5, 2026 names warfarin in its drug interactions section; warfarin's label does not name aspirin/dipyridamole itself but warns about its class (NSAIDs (nonsteroidal anti-inflammatory drugs), platelet aggregation inhibitors). The aspirin/dipyridamole label: “Aspirin can displace warfarin from protein binding sites, leading to prolongation of both the prothrombin time and the bleeding time.”

Check it at the source: the aspirin/dipyridamole FDA label on DailyMed (effective January 5, 2026, Glenmark Pharmaceuticals Inc., USA); the warfarin FDA label on DailyMed (effective May 29, 2026, Amneal Pharmaceuticals LLC).

What does the aspirin/dipyridamole label say about warfarin?

Aspirin/dipyridamole label, drug interactions

Aspirin can displace warfarin from protein binding sites, leading to prolongation of both the prothrombin time and the bleeding time.

Source: FDA drug label (ASPRIN AND EXTENDED-RELEASE DIPYRIDAMOLE), Glenmark Pharmaceuticals Inc., USA, effective January 5, 2026 (SPL set 467d6ce3-bc05-4aa1-87cc-3214fd628d39), via openFDA; the full label on DailyMed

What does the warfarin label say about aspirin/dipyridamole?

Warfarin's label does not name aspirin/dipyridamole itself; it warns about its class (NSAIDs (nonsteroidal anti-inflammatory drugs), platelet aggregation inhibitors):

Warfarin label, drug interactions

Drugs that Can Increase the Risk of Bleeding Drug Class Specific Drugs Anticoagulants argatroban, dabigatran, bivalirudin, desirudin, heparin, lepirudin Antiplatelet Agents aspirin, cilostazol, clopidogrel, dipyridamole, prasugrel, ticlopidine Nonsteroidal Anti-Inflammatory Agents celecoxib, diclofenac, diflunisal, fenoprofen, ibuprofen, indomethacin, ketoprofen, ketorolac, mefenamic acid, naproxen, oxaprozin, piroxicam, sulindac Serotonin Reuptake Inhibitors citalopram, desvenlafaxine, duloxetine, escitalopram …

Source: FDA drug label (Warfarin Sodium), Amneal Pharmaceuticals LLC, effective May 29, 2026 (SPL set 558b7a0d-5490-4c1b-802e-3ab3f1efe760), via openFDA; the full label on DailyMed

These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.

Both medicines on the record

9Aspirin/dipyridamole generic labelers
19Warfarin generic labelers
Aspirin/dipyridamoleWarfarin
Labeled forStroke preventionBlood clots (DVT and PE), Atrial fibrillation
Boxed warningNoYes
Pharmacy cost (NADAC)$0.559 per unit 25-200 mg$0.093 per tablet 2 mg tablet
Shortage nowNo current entryNo current entry

Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)

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