What the FDA labels say about taking them together
Aspirin, butalbital, caffeine and codeine and propranolol
Aspirin, butalbital, caffeine and codeine's FDA label of May 27, 2026 names propranolol in its drug interactions section; propranolol's label does not name aspirin, butalbital, caffeine and codeine itself but warns about its class (Barbiturates, Stimulants, NSAIDs (nonsteroidal anti-inflammatory drugs), Opioids (opioid agonists), platelet aggregation inhibitors). The aspirin, butalbital, caffeine and codeine label: “The hypotensive effects of beta blockers may be diminished by the concomitant administration of aspirin due to inhibition of renal prostaglandins, leading to decreased renal blood flow, and salt and fluid retention.”
Check it at the source: the aspirin, butalbital, caffeine and codeine FDA label on DailyMed (effective May 27, 2026, Bryant Ranch Prepack); the propranolol FDA label on DailyMed (effective January 15, 2026, Mylan Pharmaceuticals Inc.).
What does the aspirin, butalbital, caffeine and codeine label say about propranolol?
Aspirin, butalbital, caffeine and codeine label, drug interactionsBeta Blockers Clinical Impact: The hypotensive effects of beta blockers may be diminished by the concomitant administration of aspirin due to inhibition of renal prostaglandins, leading to decreased renal blood flow, and salt and fluid retention. Intervention: Use caution if using concomitantly. Evaluate the blood pressure and renal function of patients. Examples: Metoprolol, propranolol
Source: FDA drug label (BUTALBITAL, ASPIRIN, CAFFEINE AND CODEINE PHOSPHATE), ANDA075231 (Lgm Pharma), as published by Bryant Ranch Prepack, effective May 27, 2026 (SPL set 95a33c9b-79a6-47c7-8433-fc217950b88f), via openFDA; the full label on DailyMed
What does the propranolol label say about aspirin, butalbital, caffeine and codeine?
Propranolol's label does not name aspirin, butalbital, caffeine and codeine itself; it warns about its class (Barbiturates, Stimulants, NSAIDs (nonsteroidal anti-inflammatory drugs), Opioids (opioid agonists), platelet aggregation inhibitors):
Propranolol label, drug interactionsNon-Cardiovascular Drugs Nonsteroidal Anti-Inflammatory Drugs Nonsteroidal anti-inflammatory drugs (NSAIDS) have been reported to blunt the antihypertensive effect of beta-adrenoreceptor blocking agents.
Propranolol label, drug interactionsNonsteroidal anti-inflammatory drugs (NSAIDs) may attenuate the antihypertensive effect of beta-adrenoreceptor blocking agents.
Source: FDA drug label (Propranolol Hydrochloride), Mylan Pharmaceuticals Inc., effective January 15, 2026 (SPL set b94dcec7-7633-4a33-9cea-48161adeaf93), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Aspirin, butalbital, caffeine and codeine | Propranolol | |
|---|---|---|
| Labeled for | Pain | High blood pressure, Angina, Atrial fibrillation, Migraine |
| Boxed warning | Yes | No |
| Pharmacy cost (NADAC) | $1.00 per capsule Ascomp with codeine capsule | $0.0493 per tablet 20 mg tablet |
| Shortage now | No current entry | In shortage |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once