What the FDA labels say about taking them together
Aspirin, butalbital, caffeine and codeine and probenecid
Aspirin, butalbital, caffeine and codeine's FDA label of May 27, 2026 names probenecid in its drug interactions section; the probenecid label PlainMeds reads does not name aspirin, butalbital, caffeine and codeine. The aspirin, butalbital, caffeine and codeine label: “Concurrent use with aspirin can lead to high serum concentrations of the carbonic anhydrase inhibitor and cause toxicity due to competition at the renal tubule for secretion.”
Check it at the source: the aspirin, butalbital, caffeine and codeine FDA label on DailyMed (effective May 27, 2026, Bryant Ranch Prepack); the probenecid FDA label on DailyMed (effective January 5, 2021, Lannett Company, Inc.).
What does the aspirin, butalbital, caffeine and codeine label say about probenecid?
Aspirin, butalbital, caffeine and codeine label, drug interactionsClinical Impact: Aspirin inhibits the uricosuric effects of uricosuric agents. Intervention: Avoid concomitant use. Probenecid Carbonic Anhydrase Inhibitors Clinical Impact: Concurrent use with aspirin can lead to high serum concentrations of the carbonic anhydrase inhibitor and cause toxicity due to competition at the renal tubule for secretion. …
Source: FDA drug label (BUTALBITAL, ASPIRIN, CAFFEINE AND CODEINE PHOSPHATE), ANDA075231 (Lgm Pharma), as published by Bryant Ranch Prepack, effective May 27, 2026 (SPL set 95a33c9b-79a6-47c7-8433-fc217950b88f), via openFDA; the full label on DailyMed
What does the probenecid label say about aspirin, butalbital, caffeine and codeine?
Probenecid's label (effective January 5, 2021) does not name aspirin, butalbital, caffeine and codeine in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Probenecid), Lannett Company, Inc., effective January 5, 2021 (SPL set ab497fd8-00c3-4364-b003-b39d21fbdf38), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Aspirin, butalbital, caffeine and codeine | Probenecid | |
|---|---|---|
| Labeled for | Pain | Gout |
| Boxed warning | Yes | No |
| Pharmacy cost (NADAC) | $1.00 per capsule Ascomp with codeine capsule | $0.636 per tablet 500 mg tablet |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once