What the FDA labels say about taking them together
Aspirin/butalbital/caffeine and probenecid
Aspirin/butalbital/caffeine's FDA label of December 2, 2024 names probenecid in its drug interactions section; the probenecid label PlainMeds reads does not name aspirin/butalbital/caffeine.
Check it at the source: the aspirin/butalbital/caffeine FDA label on DailyMed (effective December 2, 2024, Sandoz Inc); the probenecid FDA label on DailyMed (effective January 5, 2021, Lannett Company, Inc.).
What does the aspirin/butalbital/caffeine label say about probenecid?
Aspirin/butalbital/caffeine label, drug interactionsButalbital, aspirin, and caffeine capsules may diminish the effects of: Uricosuric agents such as probenecid and sulfinpyrazone, reducing their effectiveness in the treatment of gout.
Source: FDA drug label (Butalbital, aspirin, and caffeine), Sandoz Inc, effective December 2, 2024 (SPL set 0e5e3842-fc6c-4a24-8e5c-522701f7c291), via openFDA; the full label on DailyMed
What does the probenecid label say about aspirin/butalbital/caffeine?
Probenecid's label (effective January 5, 2021) does not name aspirin/butalbital/caffeine in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Probenecid), Lannett Company, Inc., effective January 5, 2021 (SPL set ab497fd8-00c3-4364-b003-b39d21fbdf38), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Aspirin/butalbital/caffeine | Probenecid | |
|---|---|---|
| Labeled for | n/a | Gout |
| Boxed warning | No | No |
| Pharmacy cost (NADAC) | $0.948 per capsule 50-325-40 mg capsule | $0.636 per tablet 500 mg tablet |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once