What the FDA labels say about taking them together
Armodafinil and propranolol
Armodafinil's FDA label of September 2, 2025 names propranolol in its drug interactions section; the propranolol labels PlainMeds reads (4) do not name armodafinil. The armodafinil label: “Effects of NUVIGIL on CYP2C19 Substrates Elimination of drugs that are substrates for CYP2C19 may be prolonged by NUVIGIL via inhibition of metabolic enzymes, with resultant higher systemic exposure.”
Check it at the source: the armodafinil FDA label on DailyMed (effective September 2, 2025, Golden State Medical Supply, Inc.); the propranolol FDA label on DailyMed (effective January 15, 2026, Mylan Pharmaceuticals Inc.).
What does the armodafinil label say about propranolol?
Armodafinil label, drug interactionsEffects of NUVIGIL on CYP2C19 Substrates Elimination of drugs that are substrates for CYP2C19 (e.g., phenytoin, diazepam, propranolol, omeprazole, and clomipramine) may be prolonged by NUVIGIL via inhibition of metabolic enzymes, with resultant higher systemic exposure.
Source: FDA drug label (Nuvigil), NDA021875 (Nuvo Pharms), as published by Golden State Medical Supply, Inc., effective September 2, 2025 (SPL set 3dd49302-f757-d945-e063-6294a90afcba), via openFDA; the full label on DailyMed
What does the propranolol label say about armodafinil?
Propranolol's label (effective January 15, 2026) and its 3 other brand-application labels do not name armodafinil in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Propranolol Hydrochloride), Mylan Pharmaceuticals Inc., effective January 15, 2026 (SPL set b94dcec7-7633-4a33-9cea-48161adeaf93), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Armodafinil | Propranolol | |
|---|---|---|
| Labeled for | n/a | High blood pressure, Angina, Atrial fibrillation, Migraine |
| Boxed warning | No | No |
| Pharmacy cost (NADAC) | $0.788 per tablet 150 mg tablet | $0.0493 per tablet 20 mg tablet |
| Shortage now | No current entry | In shortage |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once