What the FDA labels say about taking them together
Argatroban and warfarin
Argatroban's FDA label of May 3, 2026 names warfarin in its drug interactions section, and warfarin's label names argatroban too. The argatroban label: “The concomitant use of argatroban and warfarin results in prolongation of the PT and INR beyond that produced by warfarin alone.”
Check it at the source: the argatroban FDA label on DailyMed (effective May 3, 2026, Hikma Pharmaceuticals USA Inc.); the warfarin FDA label on DailyMed (effective May 29, 2026, Amneal Pharmaceuticals LLC).
What does the argatroban label say about warfarin?
Argatroban label, drug interactionsHowever, the concomitant use of argatroban and warfarin (5 to 7.5 mg initial oral dose, followed by 2.5 to 6 mg/day orally for 6 to 10 days) results in prolongation of the prothrombin time (PT) and International Normalized Ratio (INR) [see Dosage and Administration (2.5 ) and Clinical Pharmacology (12.2) ].
Argatroban label, warnings and precautionsThe concomitant use of argatroban and warfarin results in prolongation of the PT and INR beyond that produced by warfarin alone [ see Dosage and Administration (2.5), Clinical Pharmacology (12.2) ].
Argatroban label (Accord Healthcare Inc., May 21, 2026), drug interactionsDRUG INTERACTIONS Heparin: Allow sufficient time for heparin's effect on aPTT to decrease before initiating Argatroban in Sodium Chloride Injection therapy ( 7.1 ) Warfarin:
Source: FDA drug label (Argatroban, NDA212035), Accord Healthcare Inc., effective May 21, 2026 (SPL set 46cdf9e6-839c-49c8-9ee1-c30cfdd9368d), via openFDA
Source: FDA drug label (Argatroban), Hikma Pharmaceuticals USA Inc., effective May 3, 2026 (SPL set 0cdf3f67-5bf3-4d58-b330-03febdc652bf), via openFDA; the full label on DailyMed
What does the warfarin label say about argatroban?
Warfarin label, drug interactionsDrug Class: Anticoagulants; Specific Drugs: argatroban, dabigatran, bivalirudin, desirudin, heparin, lepirudin
Source: FDA drug label (Warfarin Sodium), Amneal Pharmaceuticals LLC, effective May 29, 2026 (SPL set 558b7a0d-5490-4c1b-802e-3ab3f1efe760), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Argatroban | Warfarin | |
|---|---|---|
| Labeled for | n/a | Blood clots (DVT and PE), Atrial fibrillation |
| Boxed warning | No | Yes |
| Pharmacy cost (NADAC) | n/a | $0.093 per tablet 2 mg tablet |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once