What the FDA labels say about taking them together
Aprepitant and phenytoin
Aprepitant's FDA label of July 5, 2024 names phenytoin in its drug interactions section; the phenytoin labels PlainMeds reads (2) do not name aprepitant.
Check it at the source: the aprepitant FDA label on DailyMed (effective July 5, 2024, Merck Sharp & Dohme LLC); the phenytoin FDA label on DailyMed (effective October 15, 2024, Mylan Pharmaceuticals Inc.).
What does the aprepitant label say about phenytoin?
Aprepitant label, drug interactionsExamples; rifampin, carbamazepine, phenytoin
Source: FDA drug label (EMEND), NDA021549 (Msd), as published by Merck Sharp & Dohme LLC, effective July 5, 2024 (SPL set 696f9e80-9cae-403b-de9e-078343ce4713), via openFDA; the full label on DailyMed
What does the phenytoin label say about aprepitant?
Phenytoin's label (effective October 15, 2024) and its 1 other brand-application label do not name aprepitant in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Phenytek), Mylan Pharmaceuticals Inc., effective October 15, 2024 (SPL set 0f94c791-8b07-4b41-927e-c9f28bec5f60), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Aprepitant | Phenytoin | |
|---|---|---|
| Labeled for | Nausea and vomiting | Seizures and epilepsy |
| Boxed warning | No | No |
| Pharmacy cost (NADAC) | $46.42 per capsule 40 mg capsule | $0.145 per capsule 100 mg capsule |
| Shortage now | A presentation being discontinued | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once