What the FDA labels say about taking them together
Apremilast and phenytoin
Apremilast's FDA label of September 2, 2026 names phenytoin in its warnings and precautions section; the phenytoin labels PlainMeds reads (2) do not name apremilast. The apremilast label: “Use with strong cytochrome P450 enzyme inducers is not recommended because loss of efficacy may occur”
Check it at the source: the apremilast FDA label on DailyMed (effective September 2, 2026, Amgen, Inc); the phenytoin FDA label on DailyMed (effective October 15, 2024, Mylan Pharmaceuticals Inc.).
What does the apremilast label say about phenytoin?
Apremilast label, warnings and precautionsUse with strong cytochrome P450 enzyme inducers (e.g., rifampin, phenobarbital, carbamazepine, phenytoin) is not recommended because loss of efficacy may occur
Source: FDA drug label (Otezla), Amgen, Inc, effective September 2, 2026 (SPL set f6b1f516-4972-4d82-bced-113e47b41cc5), via openFDA; the full label on DailyMed
What does the phenytoin label say about apremilast?
Phenytoin's label (effective October 15, 2024) and its 1 other brand-application label do not name apremilast in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Phenytek), Mylan Pharmaceuticals Inc., effective October 15, 2024 (SPL set 0f94c791-8b07-4b41-927e-c9f28bec5f60), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Apremilast | Phenytoin | |
|---|---|---|
| Labeled for | Psoriasis | Seizures and epilepsy |
| Boxed warning | No | No |
| Pharmacy cost (NADAC) | $90.57 per tablet 30 mg tablet | $0.145 per capsule 100 mg capsule |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once