What the FDA labels say about taking them together
Apomorphine and promethazine
Apomorphine's FDA label of February 24, 2022 names promethazine in its warnings and precautions section; the promethazine label PlainMeds reads does not name apomorphine.
Check it at the source: the apomorphine FDA label on DailyMed (effective February 24, 2022, TruPharma, LLC); the promethazine FDA label on DailyMed (effective March 13, 2026, KVK-Tech, Inc.).
What does the apomorphine label say about promethazine?
Apomorphine label, warnings and precautionsAntiemetics with anti-dopaminergic actions (e.g., haloperidol, chlorpromazine, promethazine, prochlorperazine, metaclopramide) have the potential to worsen the symptoms in patients with Parkinson's disease and should be avoided.
Onapgo label (MDD US Operations, LLC, a subsidiary of Supernus Pharmaceuticals, Inc, July 10, 2026), warnings and precautionsAntiemetics with anti-dopaminergic actions (e.g., haloperidol, chlorpromazine, promethazine, prochlorperazine, metoclopramide) have the potential to worsen the symptoms in patients with Parkinson's disease (PD) and therefore the benefits and risks of treatment with these antiemetics should be carefully considered.
Source: FDA drug label (Onapgo, NDA214056), MDD US Operations, LLC, a subsidiary of Supernus Pharmaceuticals, Inc, effective July 10, 2026 (SPL set f3552b6e-5ae7-4993-aa1a-e399c4a7080a), via openFDA
Source: FDA drug label (apomorphine hydrocloride), ANDA212025 (Tp Anda Holdings), as published by TruPharma, LLC, effective February 24, 2022 (SPL set aedf70e4-1949-44bc-bf1b-0f282c4f0705), via openFDA; the full label on DailyMed
What does the promethazine label say about apomorphine?
Promethazine's label (effective March 13, 2026) does not name apomorphine in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (PROMETHAZINE HYDROCHLORIDE), KVK-Tech, Inc., effective March 13, 2026 (SPL set 7a137adf-39b7-4b14-80da-c3cac9ad562a), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Apomorphine | Promethazine | |
|---|---|---|
| Labeled for | Parkinson's disease | n/a |
| Boxed warning | No | No |
| Pharmacy cost (NADAC) | n/a | $0.0455 per tablet 25 mg tablet |
| Shortage now | No current entry | In shortage |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once