What the FDA labels say about taking them together
Apalutamide and digoxin
Apalutamide's FDA label of July 2, 2026 names digoxin in its drug interactions section; the digoxin labels PlainMeds reads (3) do not name apalutamide. The apalutamide label: “ERLEADA can interfere with certain digoxin immunoassays, resulting in falsely elevated digoxin plasma concentration results.”
Check it at the source: the apalutamide FDA label on DailyMed (effective July 2, 2026, Janssen Products, LP); the digoxin FDA label on DailyMed (effective December 5, 2024, Advanz Pharma (US) Corp.).
What does the apalutamide label say about digoxin?
Apalutamide label, drug interactionsLaboratory Test Interference ERLEADA can interfere with certain digoxin immunoassays (e.g., Chemiluminescent Microparticle Immunoassays), resulting in falsely elevated digoxin plasma concentration results.
Apalutamide label, warnings and precautionsERLEADA can interfere with certain digoxin immunoassays, resulting in falsely elevated digoxin plasma concentration results.
Source: FDA drug label (ERLEADA), Janssen Products, LP, effective July 2, 2026 (SPL set d1cda4f7-cb33-46ea-b9ac-431f6452b1a5), via openFDA; the full label on DailyMed
What does the digoxin label say about apalutamide?
Digoxin's label (effective December 5, 2024) and its 2 other brand-application labels do not name apalutamide in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (LANOXIN), Advanz Pharma (US) Corp., effective December 5, 2024 (SPL set d91e3646-4c63-4512-ab22-db39c085c4dc), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Apalutamide | Digoxin | |
|---|---|---|
| Labeled for | Prostate cancer | Heart failure, Atrial fibrillation |
| Boxed warning | No | No |
| Pharmacy cost (NADAC) | n/a | $0.133 per tablet 125 mcg tablet |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once