What the FDA labels say about taking them together
Ampicillin/sulbactam and probenecid
Ampicillin/sulbactam's FDA label of July 10, 2026 names probenecid in its drug interactions section; the probenecid label PlainMeds reads does not name ampicillin/sulbactam. The ampicillin/sulbactam label: “Drug Interactions Probenecid decreases the renal tubular secretion of ampicillin and sulbactam.”
Check it at the source: the ampicillin/sulbactam FDA label on DailyMed (effective July 10, 2026, Roerig); the probenecid FDA label on DailyMed (effective January 5, 2021, Lannett Company, Inc.).
What does the ampicillin/sulbactam label say about probenecid?
Ampicillin/sulbactam label, drug interactionsDrug Interactions Probenecid decreases the renal tubular secretion of ampicillin and sulbactam.
Source: FDA drug label (UNASYN), NDA050608 (Pfizer), as published by Roerig, effective July 10, 2026 (SPL set 155c7ec0-5862-404f-b1d0-f278f8a8bbda), via openFDA; the full label on DailyMed
What does the probenecid label say about ampicillin/sulbactam?
Probenecid's label (effective January 5, 2021) does not name ampicillin/sulbactam in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Probenecid), Lannett Company, Inc., effective January 5, 2021 (SPL set ab497fd8-00c3-4364-b003-b39d21fbdf38), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Ampicillin/sulbactam | Probenecid | |
|---|---|---|
| Labeled for | Bacterial infections | Gout |
| Boxed warning | No | No |
| Pharmacy cost (NADAC) | n/a | $0.636 per tablet 500 mg tablet |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once