Ampicillin/Sulbactam and Probenecid Interaction
Drug interaction information between Ampicillin/Sulbactam and Probenecid.
Ampicillin/Sulbactam and Probenecid have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Ampicillin/Sulbactam and Probenecid. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
One medicine slows down how fast your kidneys remove the antibiotic, which causes the antibiotic to stay in your blood longer.
FDA Label Information
Drug Interactions Probenecid decreases the renal tubular secretion of ampicillin and sulbactam. Concurrent use of probenecid with UNASYN may result in increased and prolonged blood levels of ampicillin and sulbactam.
Ampicillin/Sulbactam Also Interacts With
- Allopurinol minor
Probenecid Also Interacts With
- Ketorolac major
- Levofloxacin major
- Amoxicillin moderate
- Amoxicillin/Clavulanate moderate
- Ceftazidime/Avibactam moderate
Frequently Asked Questions
What SPL severity band is on file for Ampicillin/Sulbactam + Probenecid?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Probenecid has 37 labeled pairs on file vs Ampicillin/Sulbactam's 2. In the minor band specifically: Ampicillin/Sulbactam has 2 (also Allopurinol); Probenecid has 23 (also Theophylline, Acetaminophen/Oxycodone, Carbidopa/Levodopa, Cefazolin).
What mechanism field is on file for Ampicillin/Sulbactam and Probenecid?
One medicine slows down how fast your kidneys remove the antibiotic, which causes the antibiotic to stay in your blood longer.
Probenecid carries more major-labeled pairs than Ampicillin/Sulbactam
SPL source-record counts only. This page's band is minor · classes on file: Ampicillin/Sulbactam (Penicillin / Beta-Lactamase Inhibitor); Probenecid (Uricosuric Agent).
Probenecid has 2 major-labeled pairs vs Ampicillin/Sulbactam's 0. This page itself is in the minor band, not the major band.
0 major · 0 moderate · 2 minor · 2 total
- Other minor peers for Ampicillin/Sulbactam
- Allopurinol
2 major · 12 moderate · 23 minor · 37 total
- Other minor peers for Probenecid
- Theophylline
- Acetaminophen/Oxycodone
- Carbidopa/Levodopa
- Cefazolin
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.