What the FDA labels say about taking them together
Amphotericin b and sirolimus
Sirolimus's FDA label of January 28, 2026 names amphotericin b in its warnings and precautions section; the amphotericin b label PlainMeds reads does not name sirolimus.
Check it at the source: the amphotericin b FDA label on DailyMed (effective June 3, 2025, Heritage Pharmaceuticals Inc. d/b/a Avet Pharmaceuticals Inc.); the sirolimus FDA label on DailyMed (effective January 28, 2026, Glenmark Pharmaceuticals Inc., USA).
What does the amphotericin b label say about sirolimus?
Amphotericin b's label (effective June 3, 2025) does not name sirolimus in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Amphotericin B), Heritage Pharmaceuticals Inc. d/b/a Avet Pharmaceuticals Inc., effective June 3, 2025 (SPL set 2b2f3ff5-9d62-4ad2-8eac-1181e5911513), via openFDA; the full label on DailyMed
What does the sirolimus label say about amphotericin b?
Sirolimus label, warnings and precautionsCaution should be exercised when using agents (e.g., aminoglycosides and amphotericin B) that are known to have a deleterious effect on renal function.
Source: FDA drug label (sirolimus), Glenmark Pharmaceuticals Inc., USA, effective January 28, 2026 (SPL set 57fb4d90-3ccb-4a69-af1e-53be83f7a504), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Amphotericin b | Sirolimus | |
|---|---|---|
| Labeled for | Fungal infections | Organ transplant rejection |
| Boxed warning | No | Yes |
| Pharmacy cost (NADAC) | n/a | $0.723 per tablet 1 mg tablet |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once