What the FDA labels say about taking them together
Amphotericin b and magnesium sulfate
Magnesium sulfate's FDA label (Magnesium Sulfate In Dextrose) of August 24, 2026 names amphotericin b in its drug interactions section; the amphotericin b label PlainMeds reads does not name magnesium sulfate. The magnesium sulfate label: “• Reduced magnesium concentrations may impact efficacy”
Check it at the source: the amphotericin b FDA label on DailyMed (effective June 3, 2025, Heritage Pharmaceuticals Inc. d/b/a Avet Pharmaceuticals Inc.); the magnesium sulfate FDA label on DailyMed (effective August 24, 2026, Hospira, Inc.).
What does the amphotericin b label say about magnesium sulfate?
Amphotericin b's label (effective June 3, 2025) does not name magnesium sulfate in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Amphotericin B), Heritage Pharmaceuticals Inc. d/b/a Avet Pharmaceuticals Inc., effective June 3, 2025 (SPL set 2b2f3ff5-9d62-4ad2-8eac-1181e5911513), via openFDA; the full label on DailyMed
What does the magnesium sulfate label say about amphotericin b?
Magnesium Sulfate In Dextrose label (Hospira, Inc., August 24, 2026), drug interactionsDrugs that May Induce Magnesium Loss Clinical Impact: • Reduced magnesium concentrations may impact efficacy Intervention: • Monitor magnesium concentrations frequently and adjust the Magnesium Sulfate in 5% Dextrose Injection dosage to maintain concentrations in the target range [see ]. Examples: • Alcohol, aminoglycosides, amphotericin B, cisplatin, cyclosporine, digitalis, loop diuretics, thiazide diuretics
Source: FDA drug label (Magnesium Sulfate In Dextrose, NDA020488), Hospira, Inc., effective August 24, 2026 (SPL set 03ebeabb-8386-4af4-3086-bdf3c3fc4a5a), via openFDA
Source: FDA drug label (Magnesium Sulfate in Water), Hospira, Inc., effective August 24, 2026 (SPL set 22ca78b4-f5a3-4144-cf89-5f633acf1e6d), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Amphotericin b | Magnesium sulfate | |
|---|---|---|
| Labeled for | Fungal infections | Seizures and epilepsy, Constipation, Pain |
| Boxed warning | No | No |
| Pharmacy cost (NADAC) | n/a | $0.0039 per gram Epsom salt |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once