What the FDA labels say about taking them together
Amphotericin b and arsenic trioxide
Arsenic trioxide's FDA label of July 23, 2021 names amphotericin b in its warnings and precautions section; the amphotericin b label PlainMeds reads does not name arsenic trioxide. The arsenic trioxide label: “The risk may be increased when TRISENOX is coadministered with medications that can lead to electrolyte abnormalities.”
Check it at the source: the amphotericin b FDA label on DailyMed (effective June 3, 2025, Heritage Pharmaceuticals Inc. d/b/a Avet Pharmaceuticals Inc.); the arsenic trioxide FDA label on DailyMed (effective July 23, 2021, Amneal Pharmaceuticals LLC).
What does the amphotericin b label say about arsenic trioxide?
Amphotericin b's label (effective June 3, 2025) does not name arsenic trioxide in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Amphotericin B), Heritage Pharmaceuticals Inc. d/b/a Avet Pharmaceuticals Inc., effective June 3, 2025 (SPL set 2b2f3ff5-9d62-4ad2-8eac-1181e5911513), via openFDA; the full label on DailyMed
What does the arsenic trioxide label say about amphotericin b?
Arsenic trioxide label, warnings and precautionsThe risk may be increased when arsenic trioxide is co-administered with medications that can lead to electrolyte abnormalities (such as diuretics or amphotericin B) [see Drug Interactions (7) ].
Source: FDA drug label (Trisenox, NDA021248), Cephalon, LLC, effective October 28, 2025 (SPL set 101fc347-d0ad-4aee-8b06-9feb187fd741), via openFDA
Source: FDA drug label (Arsenic Trioxide), Amneal Pharmaceuticals LLC, effective July 23, 2021 (SPL set 5845022e-8c01-451b-ae49-a28e58c5f845), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Amphotericin b | Arsenic trioxide | |
|---|---|---|
| Labeled for | Fungal infections | Leukemia, lymphoma and myeloma |
| Boxed warning | No | Yes |
| Pharmacy cost (NADAC) | n/a | n/a |
| Shortage now | No current entry | A presentation being discontinued |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once